The originating document has been archived. Dosage and Administration Safe-Guard AquaSol must be administered orally to chickens via the drinking water at a daily dose of 1.0 mg/kg BW (0.454 mg/lb) for 5 consecutive days. Histopathologic examinations were performed on 12 hens each from the control and 5 mg fenbendazole/kg body weight groups. However, its important to follow the specified instructions on the product label and consult your veterinarian for further assistance before using it on your chickens. Chickens: Two margin of safety studies (growing broiler chickens and laying hens at peak egg production) and one reproductive safety study (broiler breeder chickens) were conducted. Swine: Safe-Guard AquaSol must be administered orally to swine via the drinking water at a daily dose of 2.2 mg/kg BW (1 mg/lb) for 3 consecutive days. http://www.merck.com/product/patent/home.html. DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. How Do You Mix Fenbendazole for Chickens? Protect from light. Add to Cart. No clinically significant effects related to the administration of Safe Guard AquaSol were observed for any of the parameters evaluated. The efficacy against adult A. galli was 90.2%. The recommended dose calculation is 1 milligram of fenbendazole per 1-kilogram chicken body weight. Jeffers Livestock offers a variety of poultry wormers including injectables, pour-ons, and other types of dewormers. Do not freeze. Broiler chickens, replacement chickens, breeding chickens , and laying hens . During treatment, all animals must have sole and unrestricted access to the medicated water. Safe-Guard AquaSol was initially approved in October 2015 for the treatment and control of adult A. galli in broiler chickens and replacement chickens intended to become breeding chickens and for the treatment and control of adult A. galli and H. gallinarum in breeding chickens. Safe-Guard AquaSol should always be measured by adding it to a measuring device that already contains an equivalent volume of water.]. Ensure that the total amount of medicated water offered is consumed. Another group of 120 chickens (60 male and 60 female) was provided non-medicated drinking water and used as a control group. It is the active ingredient used in Safe-Guard Aquasol, and it works to combat adult-stage roundworms and adult-stage cecal worms in chickens. The volume of water in the stock suspension container has to be calculated taking as a basis the present injection rate of the dosing pump and the volume of drinking water usually consumed by the animals over a period of 3 to 24 hours. Available for Android and iOS devices. It is used for the treatment and control of adult roundworms in both broiler and replacement chickens that are grown to become breeding chickens and for the treatment and control of adult roundworms and cecal worms in breeding chickens. A decrease of effectiveness over time may indicate the development of resistance to the dewormer administered. of Med. This is equivalent to 0.005 milliliters of Safe-Guard Aquasol per 1-kilogram chicken body weight in a day for 5 consecutive days. Chickens: Six pivotal dose confirmation studies and five field effectiveness studies were conducted to evaluate the effectiveness of Safe-Guard AquaSol oral suspension against adult A. galli in broiler chickens and replacement chickens and against A. galli and H. gallinarum in breeding chickens and laying hens. Easily administered by medicators or proportioners. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Contact your veterinarian for further assistance in the control and treatment of worms. Chickens: Safe-Guard AquaSol must be administered orally to chickens via the drinking water at a daily dose of 1 mg/kg BW (0.454 mg/lb) for 5consecutive days. Three dose confirmation studies were conducted in European Union (EU), using 105 Rhode Island Red breed hens (2 years old) for each study. RESIDUE WARNING: No withdrawal period is required when used according to labeling. replacement chickens and for the treatment and control of adult A. galli and Heterakis gallinarum in breeding chickens and laying hens. [Note: If the total volume of the 1 to 1 dilution needed exceeds the volume of the largest available measuring device, divide the total volume into two or more smaller batches of 1 to 1dilution, prepared following the steps below. The amount of FBZ Suspension administered in drinking water to the study pigs was calculated from pre-treatment body weights. For Patent Information: http://www.merck.com/product/patent/home.html. Fenbendazole (active ingred.) If the administration period exceeds 8 hours, but being no longer than 24 hours, the stock suspension container needs to be equipped with a stirring device. The amount of FBZ Suspension administered in drinking water to the study pigs was calculated from pre-treatment body weights. The parameters evaluated in the study included feed and water intake, body weights, clinical health, egg production and weight, fertility, hatchability, and 14-day old chick viability. The withdrawal period refers to the time you need to take before consuming eggs produced by hens that are treated with the product, just in case the active ingredient has any effect on egg taste, safety, and quality. 99. Six pens of 2 pigs each were used per treatment group. SafeGuard AquaSol . Updated: 2023-02-28. Safeguard is usually administered orally, I do it with an oral syringe. Ensure that the total amount of medicated water offered is consumed. The efficacy against adult A.galli was 100%. if(typeof ez_ad_units != 'undefined'){ez_ad_units.push([[250,250],'farmandchill_com-large-mobile-banner-2','ezslot_12',107,'0','0'])};__ez_fad_position('div-gpt-ad-farmandchill_com-large-mobile-banner-2-0'); Safe-Guard Aquasol requires oral administration to chickens by mixing it with their water first before letting them consume it. To view our complete product lineup, click to viewour POULTRY PRODUCT CATALOG vol. At concentrations of up to 5 mL/L stock suspension (1 g fenbendazole/L) no stirring is required. For three-day fenbendazole treatments, dissolve 1.2 ounces of fenbendazole product (Safe-Guard Aquasol or Panacur) for every 100 pounds of feed, every day for 3 days. RESIDUE WARNING: Chickens: No withdrawal period is required when used according to labeling. At the end of the treatment phase, 30 breeding chickens (10 male and 20 female) from each group were necropsied; and gross pathology and weights of testes and female reproductive tracts were evaluated. The margin of safety in laying hens was conducted in 144 laying hens. Adequacy of infection was demonstrated at both study sites by having more than 6 non-medicated pigs (11 of the 12 non-medicated animals in MN and 9 of the 12 non-medicated animals in CA) with adult T. suis worm counts of 100 or more per animal. There were no abnormal observations made at the California (CA) site on pigs after FBZ administration. Palatability: A pivotal palatability study was conducted to evaluate the palatability of 20% Fenbendazole Suspension in pigs through voluntary consumption of medicated water when offered for approximately 5 hours a day over 3 consecutive days at a dose of 2.2 mg fenbendazole/kg body weight (BW) per day (label dose). The daily dose is 2.2mg fenbendazole per kg BW (1 mg/lb) which is equivalent to 0.011mL Safe-Guard AquaSol per kg BW (0.0045 mL/lb).The required daily volume of product is calculated from the total estimated body weight [kg] of the entire group of pigs to be treated. Another group of 110 breeding chickens (10 male and 100 female) were provided non-medicated drinking water and used as a control group. Use the medicated water within 24 hours. At concentrations from 5 mL up to 75 mL of product /L stock suspension (1,000 mg to 15,000 mg fenbendazole/L) and within up to 8 hours during the treatment administration period no stirring of the stock suspension is required. A fifth dose confirmation study was conducted in the US using 176 Cobb breed broiler chickens (4 to 5 weeks old). 6) Add the 1 to 1 dilution of Safe-Guard AquaSol in water to the water supply system as described below. Copyright 2015, 2017 Intervet Inc. a subsidiary of Merck & Co., Inc., Madison, NJ 07940, Distributed by: Intervet Inc., 2 Giralda Farms, Madison, NJ 07940, Copyright 2023 Animalytix LLC. Accidental ingestion may cause gastrointestinal disturbances and hypersensitivity reactions in humans. The reproductive safety in broiler breeding chickens was conducted in 220 broiler breeder chickens. The pivotal dose confirmation studies and field effectiveness studies demonstrated substantial evidence of effectiveness of Safe-Guard AquaSol at the dose of 1 mg fenbendazole/kg body weight/day for 5 consecutive days against adult A. galli in broiler chickens and replacement chickens and against adult A. galli and H. gallinarum in breeding chickens and laying hens. The medicated water should appear hazy. Safe-Guard AquaSol is indicated for the treatment and control of adult Ascaridia galli and Heterakis gallinarum. Prepare a 1 to 1 dilution (pre-dilution) of Safe-Guard AquaSol in water: 1) Calculate the volume of Safe-Guard AquaSol to be administered daily. Products for Farrowing and Breeding Swine, Swine Ear Tags, Marking, & Identification Products, Skip to the beginning of the images gallery. Swine: A multi-site, masked, negative-controlled dose confirmation field study was conducted to provide substantial evidence of the effectiveness of Fenbendazole (FBZ) Suspension (20% w/v) administered orally in drinking water to pigs for three consecutive days to provide a dose of 2.2 mg FBZ/kg body weight daily against the dose-limiting worm Trichuris suis (T. suis). Fenbendazole for Chickens and Ducks Brand Names: Panacur, Safeguard Drug Type: Anthelmintic Fenbendazole Overview Fenbendazole (brand names Panacur and Safe-Guard) is a benzimidazole anthelmintic used 'off label' to treat a variety of intestinal parasites (e.g., roundworms, flukes, certain types of tapeworms, and Giardia) in pet poultry. Most parasites are very easily picked up in the environment, so a single negative test doesn't mean they will never pick them up. In the study, the efficacy against adult A. galli and H. gallinarum was 98.7% and 99.2%, respectively. There was a significant treatment effect in T. suis worm counts between medicated and non-medicated treatment groups at each study site (p=0.0006 in MN and p=0.0003 in CA). These studies supported the safety of Safe-Guard AquaSol in broiler chickens, replacement chickens, laying hens and breeding chickens when administered in drinking water at 1 mg fenbendazole/kg body weight/day for 5 consecutive days. 3) Pour a volume of water equal to the calculated volume of product needed into the measuring device. Fenbendazole is safe to use for chickens. That will treat capillaria worms and ascarids. Necropsy of unhatched eggs was performed to record the percentage of dead embryos and dead and culled hatchlings. In all three studies, the efficacy against A.galli (97.9%, 97.3%, and 93.9%) and H. gallinarum (99.8%, 96.9%, and 97.3%) was greater than 90%. Six pens of 2 pigs each were used per treatment group. In the study, the efficacy against adult A. galli was 99.4%. They can cause problems such as weight loss, diarrhea, anemia, and a decline in egg production among chickens. Another group of 120 chickens (60 male and 60 female) was provided non-medicated drinking water and used as a control group. UIN#. made in China. Use the medicated water within 24 hours. Histopathologic examinations were performed on 48 chickens each from the control and 5 mg fenbendazole/kg body weight groups. 2023 Best Veterinary Solutions, Inc.All Rights Reserved. Individual fecal samples were obtained from each candidate animal 46, 47, and 48 days after T. suis inoculation and analyzed for the presence of T. suis eggs. Safe-Guard AquaSol was administered orally as medicated drinking water to a group of 110 breeding chickens (10 male and 100 female) at 3 mg fenbendazole/kg body weight/day (3 times the recommended label dose) for 21 consecutive days (4 times the recommended duration). Smaller particle size helps prevent sedimentation and clogged pipes, filters or nipple drinkers. Follow the instructions in the order described below to prepare the medicated water. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Family owned since 1975. In all three studies, the efficacy against A.galli (97.9%, 97.3%, and 93.9%) and H. gallinarum (99.8%, 96.9%, and 97.3%) was greater than 90%. There were no abnormal observations made at the California (CA) site on pigs after FBZ administration. No withdrawal period is required when used according to labeling. For customer service, adverse effects reporting, and/or a copy of the SDS, call 1-800-211-3573. The two animals assigned to the same treatment group within the same weight block were then assigned to the same pen. Zyfend A, 30 mL. For customer service, adverse effects reporting, and/or a copy of the SDS, call 1-800-211-3573. For Patent Information: http://www.merck.com/product/patent/home.html. Do You Need to Deworm Chickens Regularly? It is specifically indicated by the manufacturer that Safe-Guard Aquasol should not be used for laying hens and replacement chickens that are groomed to become laying hens. 3) Pour a volume of water equal to the calculated volume of product needed into the measuring device. Fifty-six days prior to treatment administration, all suitable study candidates were orally dosed with approximately 4000 embryonated T. suis eggs. The average percent of medicated water consumed was 98.18%, thus the study demonstrated that 20% Fenbendazole Suspension has acceptable palatability. Sultan Chickens | Theyll Steal Your Heart and Your Flocks Attention, Inspection of intestinal lining and necropsy of suspect birds, Inspection of feces, finding worms in the ceca or its eggs, and necropsy of suspect birds, Weakness, unthriftiness, weight loss, loss of feed efficiency, Inspection of the birds trachea and finding distinct red worms in them, Gasping, open-mouthed or labored breathing, coughing, grunting, Inspection by finding large numbers of worms through necropsy or worm eggs in the birds feces, Inflammation of joints or oral cavity, weight loss, beak droopiness, weight loss, diarrhea, mottled egg yolks, Inspection of tapeworm segments in the intestine or feces. Safe-Guard AquaSol was administered orally as medicated drinking water to three groups of 120 chickens (60 male and 60 female in each group) at 1, 3, and 5 mg fenbendazole/kg body weight/day (1, 3, and 5 times the recommended label dose) for 15 consecutive days (3 times the recommended duration). Here are the various types of worms, their appearance, how theyre clinically diagnosed, and their associated symptoms: You can use Safeguard on chickens. You cannot eat eggs if chickens have worms. When put into water, each one will settle out because they are suspensions (suspended for a time in water.) The efficacy against adult A. galli and H.gallinarum was 100% and 88.9%, respectively. The medicated water should appear hazy. Stir the medicated water in the medication tank until the medicated water is visibly homogeneous. A common protocol was implemented in two different geographical locations and with two different investigators. Safe-Guard AquaSol must be administered orally to chickens via the drinking water at a daily dose of 1.0 mg/kg BW (0.454 mg/lb.) Safeguard is a known and proven effective dewormer that can be administered daily. DESCRIPTION: Safe-Guard AquaSol is a suspension concentrate containing fenbendazole, an antiparasitic. 3) Pour a volume of water equal to the calculated volume of product needed into the measuring device. $ 32. Swine: Safe-Guard AquaSol is indicated for swine, except for nursing piglets, for the treatment and control of: Lungworms: Adult Metastrongylus apri, Adult Metastrongylus pudendotectus; Gastrointestinal worms: Adult and larvae (L3, L4 stages, liver, lung, intestinal forms) large roundworms (Ascaris suum); Adult nodular worms (Oesophagostomum dentatum, O. quadrispinulatum); Adult small stomach worms (Hyostrongylus rubidus); Adult and larvae (L2, L3, L4 stages - intestinal mucosal forms) whipworms (Trichuris suis), and Kidney worms: Adult and larvae Stephanurus dentatus. All rights reserved. Safeguard is a known and proven effective dewormer that can be administered daily. Please use the following formula: Total estimated body weight [kg] of the chickens to be treated x 0.005 mL = mL Safe-Guard AquaSol/day, Volume of Safe-Guard AquaSol (for 5 days). It may not display this or other websites correctly. Weaned, growing-finishing pigs of approximately 6 weeks of age were used in the study. Hematology and clinical chemistry parameters were evaluated in 12 hens from each group. -> at 20%, this would be 0.00227mL of product/lb, which might be a . Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. Hematology and clinical chemistry parameters were evaluated in 24 chickens from each group. There was a significant treatment effect in T. suis worm counts between medicated and non-medicated treatment groups at each study site (p=0.0006 in MN and p=0.0003 in CA). Coop & Run - Design, Construction, & Maintenance, Coop De Chickenville~My Favorite Chickens and Life, Current Social Media Chicken Feed Craze - posted testing results. See attached Product Information Insert for complete directions and warnings before using. Each study site selected pigs from one source herd verified to be free of T. suis infection. 2018 Pipestone Veterinary Services. We comply with the HONcode standard for trustworthy health information. For the best experience on our site, be sure to turn on Javascript in your browser. JavaScript seems to be disabled in your browser. I read on this site 1/4 cc/ml per pound per bird, for 5 straight days, is that correct? Safe-Guard Aquasol provides deworming through oral administration via drinking water. INDICATIONS: Chickens: Safe-Guard AquaSol is indicated for the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens and for the treatment and control of adult A. galli and Heterakis gallinarum in breeding chickens and laying hens. CUSTOMER SERVICE. Another group of 110 breeding chickens (10 male and 100female) were provided non-medicated drinking water and used as a control group. The efficacy against adult A. galli was 100%. I happen to have a 10 ml pipet and a 100 ml volumetric flask as well as 1 ml and 3 ml syringes so it's rather simple for me to do the dilutions. Once opened, do not store the container above 25C (77F). The daily dose of 2.2 mg fenbendazole per kg BW (1 mg/lb) which is equivalent to 0.011mL Safe-Guard AquaSol per kg BW (0.0045 mL/lb).The required daily volume of product is calculated from the total estimated body weight [kg] of the entire group of pigs to be treated. A fifth effectiveness study was conducted in the US using 550 Cobb breed broiler chickens (4 to 5 weeks old). Histopathologic examinations were performed on 48chickens each from the control and 5 mg fenbendazole/kg body weight groups. The following formula should be used to estimate the dose: Total estimated body weight of the chickens in kilograms x 0.005 mL = amount of Safe-Guard Aquasol to use in milliliters in a day. Surely SOMEONE out there has calculated "if I add X ml to Y ounces of water, the dosage is Z ml per average 6 lb bird", or something to that effect. Innovative manufacturing process enables easy, effective deworming for broilers, breeders, pullets and laying hens through oral administration via drinking water. Its best to use industry-produced deworming products instead, such as Safe-Guard Aquasol. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or http://www.fda.gov/AnimalVeterinary/SafetyHealth. | Beginners Guide to High-Quality Meat. Do Hens Need a Rooster to Lay Eggs? A complete feed, adequate to meet the nutritional needs of the study animals, was offered to the animals in self-feeders throughout the study. A sixth dose confirmation study was conducted in the US using 176 Ross breed broiler chickens (4 to 5 weeks old). For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or http://www.fda.gov/AnimalVeterinary/SafetyHealth. This way, youll lessen the amount of deworming stress they undergo. The efficacy against adult A. galli was 90.2%. To anyone thinking of getting one of those cute little coops. Why Goats Love to Jump | How High Can They Go? For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or http://www.fda.gov/AnimalVeterinary/SafetyHealth. Every effort has been made to ensure the accuracy of the Safe-Guard AquaSol for Chickens information published above. In the study, the efficacy against adult A. galli was 99.4%. Each mL of Safe-Guard AquaSol contains 200 mg of fenbendazole. The margin of safety in laying hens was conducted in 144 laying hens. (fenbendazole oral suspension), For oral administration via drinking water. For the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens and for the treatment and control of adult A. galli and Heterakis gallinarum in breeding chickens and laying hens . Histopathologic evaluations were performed on the gross lesions collected during the necropsy. If you do not know what type of worms your flock has, that's something an avian vet can assist you with. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. At the end of the treatment phase, gross necropsies were performed on 12 hens from each group, and organs weights were evaluated. The volume of water in the stock suspension container has to be calculated taking as a basis the present injection rate of the dosing pump and the volume of drinking water usually consumed by the animals over a period of 3 to 24 hours. All dewormers require accurate dosing for best results. Neither SafeGuard or Valbazen is water soluble. No withdrawal time is required for consumption of eggs or meat from treated birds when administered according to label directions. And what is the egg withdrawal at that dosage, please? 8713184147011. A fourth dose confirmation study was conducted in the United States (US) using 264 Rhode Island Red breed hens (12 months old). Stir the medicated water in the medication tank until the medicated water is visibly homogeneous. Animals with at least two fecal examinations positive for T. suis eggs were eligible for inclusion in the study. Is There an Egg Withdrawal Period After Using Safeguard? Necropsy of unhatched eggs was performed to record the percentage of dead embryos and dead and culled hatchlings. Fenbendazole is a non-FDA approved, off label . These studies supported the safety of Safe-Guard AquaSol in broiler chickens, replacement chickens, laying hens and breeding chickens when administered in drinking water at 1 mg fenbendazole/kg body weight/day for 5 consecutive days. In this case, you would have to deworm your older chickens first before deworming the baby chicks. The efficacy against adult A. galli was 90.2%. (GROSS PIC WARNING), Narrowing down respiratory illness & oxytetracycline question. Use within 6 months after opening. At the end of the treatment phase, 30 breeding chickens (10 male and 20female) from each group were necropsied; and gross pathology and weights of testes and female reproductive tracts were evaluated. Protective gloves should be used and care should be taken when handling the product to avoid skin and eye exposure and accidental ingestion. Housing, management, and husbandry procedures were typical of commercial production practice. Barrow and gilt breeds representative of U.S. commercial production were used. Fenbendazole. Be careful to avoid any accidental spill or loss of 1 to 1 dilution which may inadvertently result in less than the required dose of fenbendazole. Swine: Safe-Guard AquaSol is indicated for swine, except for nursing piglets, for the treatment and control of: Lungworms: Adult Metastrongylus apri, Metastrongylus pudendotectus; Gastrointestinal worms: Adult and larvae (L3, L4 stages, liver, lung, intestinal forms) large roundworms (Ascaris suum); Adult nodular worms (Oesophagostomum dentatum, O. quadrispinulatum); Adult small stomach worms (Hyostrongylus rubidus); Adult and larvae (L2, L3, L4 stages - intestinal mucosal forms) whipworms (Trichuris suis), and Kidney worms: Adult and larvae Stephanurus dentatus. The development of resistance to the study demonstrated that 20 % fenbendazole has. 6 weeks of age were used per treatment group within the same weight block were assigned!, is that correct effects related to the same treatment group water to water... Cause gastrointestinal disturbances and hypersensitivity reactions in humans, respectively study site selected pigs one. 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