2017;354:16571, 19. Metab., 101 (2016), pp. Journal of Family Medicine and Primary Care, Get new journal Tables of Contents sent right to your email inbox, Journal of Family Medicine and Primary Care | Published by Wolters Kluwer , www.who.int/mediacentre/factsheets/fs312/en/. Of all the patients 17 were already considered to be deficient in B12. One standard first-line treatment for diabetes is metformin, which was reported to increase the risk for vitamin B12 deficiency. People with diabetes taking metformin are at a higher risk of developing B12 deficiency, because this medication can reduce vitamin B12 absorption in the body . WebVitamin B12 is a water-soluble vitamin involved in DNA synthesis, haematopoiesis and neurological function. BMC Pharmacol Toxicol. J Pak Med Assoc. eCollection 2019. Causes and pathophysiology of vitamin B12 and folate deficiencies. E-mail: [emailprotected]. Identification of Microbiota Biomarkers With Orthologous Gene Annotation for Type 2 Diabetes. We used a researcher-administered questionnaire to obtain information on patients age, sex, HIV status, diabetes type and diabetes duration. This vitamin is essential for the proper functioning of the body. Associations between B12 deficiency and age, duration of T2DM, duration of use and dosage of metformin, and use of proton pump inhibitors (PPIs) were determined. Also, add a good amount of green leafy vegetables to your diet. Vitamin B12 levels were measured by chemiluminescence immunoassay. How common is vitamin B-12 deficiency? Another serious thing that may happen to vitamin B12 deficient people is loss of smell and taste sensations. Table 2 shows factors associated with Vitamin B12 deficiency among diabetes patients at Princess Marina Hospital diabetes clinic on bivariate analyses. No matter whether you have diabetes or not, never ignore peripheral and diabetic neuropathy. When it comes to increasing the level of vitamins for diabetes, people usually take supplements. Journal of Clinical Endocrinology and Metabolism 2016. All rights reserved. Ahmed M, Muntingh G, Rheeder P. Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy BMC Pharmacol Toxicol. 2010;103:2657, 7. Some error has occurred while processing your request. Office of Dietary Supplements. Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. Not feeling as hungry as usual. There was no vitamin B12 deficiency in 53 (45.4%) of the patients. The two tests are recommended to evaluate intracellular vitamin B12 status better, especially in borderline vitamin B12 deficiency.Citation54 Parietal cell and intrinsic factor antibodies status were not correlated with the confirmed vitamin B12-deficient patients to exclude them from this study due to the unavailability of antibody tests in our local setting. 2010;340:c2181, 14. Metformin and vitamin B12 deficiency: where do we stand? Short-term memory loss. To assess the knowledge and practice of physicians about screening for vitamin B12 deficiency in metformin-treated diabetic patients, a self-administered questionnaire was distributed to all physicians conducting diabetic clinics in above-mentioned hospitals. government site. 2017;9:725, 24. 1754-1761, 10.1210/jc.2015 Severe peripheral neuropathy has, however, been reported among T2DM patients.Citation5052 This is common among patients on metformin due to drug-induced vitamin B12 deficiency.Citation50,Citation53 Vitamin B12 deficiency causes elevated homocysteine and methylmalonic acid, which has been shown to have potentially toxic effects on neurons. Elsaier A, Elamami A, Zaid A. Vitamin B12 deficiency in patients with type 2 diabetes on metformin therapy Ibnosina J Med Biomed Sci. Estimation of Serum Vitamin B12 Levels Among the Elderly Population of Wardha City: A Cross-Sectional Study. The recommended daily amount of vitamin B-12 for adults is 2.4 micrograms. The cumulative dose of metformin during the study period is not an accurate reflection of the dose taken/compliance as a pill count (counting returned tablets) or prescription filling was not correlated, and hence the resultsshowing no significant difference between the sufficient and deficient B12 groupsshould be interpreted with caution. It is because diabetics mostly take metformin, which is a well-known treatment of Type-2 diabetes. Epub 2015 Aug 2. By using metformin for a long period, the absorption of vitamin B12 will be reduced in your body. Mellitus Diabetic patients can easily develop a B12 deficiency as they are at a higher risk. Therefore, we focused on the other objectives of the study. The calculated sample size was 363. Diabetic patients are at risk of becoming more vitamin B12 deficient to various problems. Did you know that with a free Taylor & Francis Online account you can gain access to the following benefits? Experiencing nausea, vomiting or diarrhea. WebConclusion: Among patients with type 2 diabetes using metformin, the prevalence of vitamin B12 deficiency is higher than compared with patients not using metformin. In anemic conditions, the body automatically produces antibodies against the vitamin B12 carrier, i.e., Intrinsic Factor (IF). 405412. [4] Both American and European guidelines recommend metformin as the first-line agent for the pharmacological management of T2DM. The mean serum vitamin B12 level of all 16 patients was 558.46 318.01 pg/mL (range of 1741288 pg/mL). The only way to recover from your condition of hyperhomocysteinemia is by taking a regular dose of vitamin B12, vitamin B6, and folic acid. Means RT Jr, et al. Vitamin B12 deficiency symptoms Symptoms due to anaemia These are caused by the 2021 Jul 15;12(7):916-931. doi: 10.4239/wjd.v12.i7.916. The high consumption of meat among the Botswana population may explain the lower prevalence of vitamin B12 in our population than in other African settings. American Diabetes Association. 2017Last accessed on 2019 Jan 28 Available from: 3. There are a few different options as far as how you can treat your vitamin b12 deficiency if you are diabetic. If we combine this information with your protected Sharma R, Wanjari MB, Raut A, Gujar S, Gledina A, Kantode VV, Munjewar PK. Diabetes Care 2012. 34 The prevalence of anemia and mean corpuscular volume did not differ between T2DM-met patients with and without B12 deficiency (23.1% versus 31.3% and 89.4 fl versus 89.0 fl, respectively). Using an assumed proportion of 9.4% (prevalence of vitamin b12 in T2DM patients on metformin), precision of 3% and an alpha of 5%. Clipboard, Search History, and several other advanced features are temporarily unavailable. -, Ko SH, Ko SH, Ahn YB, Song KH, Han KD, Park YM, Ko SH, Kim HS. The countries in the MENA region now have some of the highest rates of diabetes. 8600 Rockville Pike Consult your doctor to analyze the blood sample report to assess the level of essential vitamins and minerals. Vitamin deficiency anemia is a lack of healthy red blood cells caused by lower than usual amounts of vitamin B-12 and folate. 2008;89:693S6S, 29. A skilled professional, Dr. Barnett holds certification from the American Board of Internal Medicine with a special focus on endocrinology, diabetes, and metabolism. Through this, not only your vitamin B12 level can be examined, but also your folate level does. Certain drugs may lead to This content does not have an Arabic version. When taken at appropriate doses, vitamin B-12 supplements are generally considered safe. The site is secure. You dont have to take Vitamins supplements if you are facing a minor B12 deficiency. He is also a recipient of several awards and honors. There were 107 patients (29.5%) who were on PPIs. Low vitamin B12 levels can worsen some symptoms of Parkinson's disease, especially postural instability and cognitive impairment, which can lead to falls and injuries, researchers say.Lower vitamin B12 levels also are associated with higher Hoehn-Yahr stage, the tool for assessing disease severity, and neuropathy in Epub 2015 Mar 9. Disclaimer. 2003;(4):CD004514. Diabetes patients are often exposed to metformin, as it is an oral medication for hyperglycemia. Adults with type 2 diabetes and low levels of vitamin B12 could be more likely to experience cardiovascular autonomic neuropathy (CAN), according to new findings. Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et alAmerican Diabetes Association; European Association for Study of Diabetes. Associations between B12 deficiency and age, duration of type 2 diabetes mellitus (T2DM), duration of use and dosage of metformin, and use of proton pump inhibitors (PPIs) were determined. Forty-four (44.0%) of the respondents know the current recommendation of ADA on vitamin B12 screening and supplementation among diabetic patients, 39 (39.0%) do not know about the current recommendation, whereas 17 (17.0%) have no idea about the recommendation. Search for Similar Articles Their mean daily dose of metformin was 828.13 150.52 mg (range of 5001000 mg). The data collection was done in the clinic using a data extraction form. 69 Vitamin B12 deficiency could be a modifiable risk factor for neuropathy in those patients. (10.3346/jkms.2014.29.7.965) Antiparietal cell antibodies occur in 90% of patients with pernicious anemia but in only 5% of healthy adults. Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine. The prevalence rate of serum B12 deficiency and peripheral neuropathy was obtained as the total number of existing cases per total number of participants in the study, respectively. It presents with Nervo M, Lubini A, Raimundo F, Moreira Faulhaber G, Leite C, Fischer L, et al Vitamin B12 in metformin-treated diabetic patients: A cross-sectional study in Brazil Rev Assoc Med Bras. To make your body function smoothly, you should also take medications for the effective absorption of B12. Facts & Comparisons eAnswers. Diabetic neuropathy is a debilitating complication of diabetes mellitus that affects about 50 % of diabetic patients, Diabetes Prevention program research group: long-term metformin use and vitamin B12 deficiency in the diabetes prevention program outcomes study. The current study was done in an urban setting, and hence the results may not be generalised to the rural population. J Pharm Technol. Vitamin B12 level was lower in type 2 diabetic patients on metformin compared to those on other oral anti-diabetic drugs, but without significant deficiency. Vitamin B(12) deficiency associated with concomitant metformin and proton pump inhibitor use Diabetes Care. WebVitamin B 12 deficiency, (IR) and those without. PN was significantly associated with female gender and poor glycemic control and was not associated vitamin B12 deficiency or metformin use. Epub 2021 Nov 24. Allen LH. Vitamin B12 levels were checked in all the patients and value of 150 pmol/L was taken as normal. Is an oral medication for hyperglycemia for Similar articles Their mean daily dose of metformin was 828.13 mg. Are temporarily unavailable: where do we stand can be examined, also., i.e., Intrinsic Factor ( if ) a Cross-Sectional study involved in DNA synthesis haematopoiesis... And folate with a free Taylor & Francis Online account you can treat your vitamin B12 deficient people is of... Arabic version Francis Online account you can treat your vitamin B12 deficient various. 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